Artem Dinh

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Bringing clarity and precision to cancer diagnostics through mechanobiology and machine learning

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Evaluation of a polarization-enhanced laparoscopy prototype for improved intra-operative visualization of peritoneal metastases

Scientific Reports - Evaluation of a polarization-enhanced laparoscopy prototype for improved intra-operative visualization of peritoneal metastases

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www.spiedigitallibrary.org

Polarization-enhanced laparoscopy yields promise for improved visualization of peritoneal cancer metastases

While white light laparoscopy (WLL) has been established as a method that yields improved detection of peritoneal metastatic lesions over radiographic imaging, its sensitivity and specificity remain sub-optimal, leading to thousands of cancer patients that are over- or under- treated every year. We present studies that establish the sensitivity of polarization enhanced (PEL) laparoscopy to changes in the cross-section and alignment of scattering centers using phantoms and report on our initial in vivo human feasibility trial. The design of our PEL probe is simple and highly compatible with current laparoscopes, the standard of patient care and the established procedure flow for WLL. It comprises of a sheath inserted on the WLL laparoscope to provide linearly polarized illumination and a modified detection optical path that allows for recording of co- and cross-polarized images relative to the incident illumination. The sum of these images is equivalent to WLL, while their difference corresponds to PEL. Using PDMS phantoms with features that contain either TiO2 and ZnO2 particles, we demonstrate the enhanced sensitivity of PEL to scattering cross-section differences. Measurements performed with collagen gels that are being stretched reveal improved sensitivity of PEL (over WLL) to collagen fiber alignment. Our initial feasibility study results support the improved diagnostic potential of PEL. In fact, a Monte Carlo-based analysis approach that utilizes the color content of the PEL images indicates that PEL yields improved contrast for detection and differentiation of benign and malignant metastatic lesions. These studies provide strong motivation for further development of PEL imaging as an approach that may improve significantly the detection of peritoneal metastatic lesions.

www.spiedigitallibrary.org

Tufts students express disappointment by university response to war in Ukraine - The Tufts Daily

“Tufts, speak up! Stop the war!” chanted acrowd of Tufts students, faculty and other community members during a rally at Mayer Campus Center last Wednesday, March 2. They gathered to show their support for Ukraine and to express their disappointment in the Tufts administration’s response to the war, hoping to prompt action.

www.tuftsdaily.com

‘Tufts Concert for Ukraine’ rages against apathy - The Tufts Daily

The walk to the auditorium was a quiet one — and cold. The rain-smelling April 16 night gave little notice that any kind of event, let alone a heavily promoted concert to support Ukraine amid the 2022 Russian invasion, was about to begin. It was only as the streetlamps leading to the Granoff Music Center fizzled to life that the open door to the center came into view.

www.tuftsdaily.com

Razom for Ukraine on Instagram: "The Razom Advocacy team has already started preparing for the next #UkraineActionSummit! In anticipation of the next Summit, we want to highlight the advocates who visited the attended the Ukraine Action Summit this April. @artemdnh is studying at @TuftsUniversity and is a member of SUSTA — Ukrainian Students of America. He has been fundraising and raising cultural awareness about Ukraine. He came to the Summit for the opportunity to network and learn more about advocacy work from the workshops. Join us at the next Summit that will take place in Washington DC on October 22-24! #UkraineActionSummit #RazomAdvocacy #AmericanCoalitionForUkraine"

263 likes, 5 comments - razom.for.ukraine on July 18, 2023: "The Razom Advocacy team has already started preparing for the next #UkraineActionSummit! In anti..."

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